Genetic Risk Score for Coronary Heart Disease: Review

Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk Estimates

A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses

BACKGROUND Comparison of patients with coronary heart disease and controls in genome-wide association studies has revealed several single nucleotide polymorphisms (SNPs) associated with coronary heart disease. We aimed to establish the external validity of these findings and to obtain more precise risk estimates using a prospective cohort design. METHODS We tested 13 recently discovered SNPs ...

Prevalence of major coronary heart disease risk factors in Iran

Background and aims: Coronary heart diseases (CHDs) contribute to mortality, morbidity, disability, productivity and quality of life. This study was aimed to determine the prevalence of major risk factors for CHD in the provinces of Iran. Methods: This study reported pre-existing data and was of secondary, descriptive type. Prevalence of non-communicable disease (NCD) risk factors was def...

Literature-Based Genetic Risk Scores for Coronary Heart Disease

Multilocus genetic risk scores for coronary heart disease prediction.

OBJECTIVE Current guidelines do not support the use of genetic profiles in risk assessment of coronary heart disease (CHD). However, new single nucleotide polymorphisms associated with CHD and intermediate cardiovascular traits have recently been discovered. We aimed to compare several multilocus genetic risk score (MGRS) in terms of association with CHD and to evaluate clinical use. APPROACH...